Professor Ernst Wolvetang

Senior Group Leader

Australian Institute for Bioengineering and Nanotechnology

+61 7 334 63894

e.wolvetang@uq.edu.au

Researcher biography

Professor Wolvetang is an international leader in the area of pluripotent stem cell biology and human functional genomics. he initiated and leads Cell Reprogramming Australia, a collaborative framework that facilitates induced pluripotent stem cell research in Australa and is co-director of the UQ Centre in Stem Cell Ageing and Regenerative Engineering (StemCARE). He has extensive expertise in reprogramming somatic cells, differentiation and tissue engineering with adult, embryonic and induced pluripotent stem cells, genome manipulation with CRISPR, molecular biology, transcriptome analysis, high content image analysis, development and use of microfluidic devices for cell analysis, nanoparticle and scaffold design and delivery, and stem cell and cell-free regenerative medicine approaches.Professor Wolvetang has been instrumental in establishing and enabling the technology for derivation of induced pluripotent stem cells across Australia. Professor Wolvetang made the strategic decision to focus on the generation of induced pluripotent stem from patients with neurological and cardiac disorders because live human cells from such patients can usually not be obtained whereas induced pluripotent stem cells have the ability to generate every cell type of the human brain in unlimited amounts and can recapitulate the disease in the dish. Induced pluripotent stem cells combined with emerging technologies such as CRISPR-based genome editing offers a unique opportunity to study the role of individual genes and combinatorial gene regulatory pathways in the eatiology of monogenic and complex brain disorders. Indeed, combined with RNA-seq and organoid generation we are now for the first time able to gain insight into gene regulatory pathways operational in individual brain cell types of healthy and diseased individuals, investigate the connectivity and function of cells, as well as pinpoint where and when during early development such deregulated pathways lead to pathological changes. Induced pluripotent stem cells further not only provide insight into the underlying pathogenesis of neurological disorders but also constitute a valuable drugscreening platform and, following CRISPR-based gene correction, can form the basis of patient specific cellular therapies for currently incurable diseases.

Professor Wolvetang received his PhD in 1992 from the Department of Biochemistry, University of Amsterdam for his original work on peroxisomal disease (6 papers). He undertook postdoctoral studies at the Department of Biochemistry and the Institute for Reproduction and Development of Monash University, investigating apoptosis, Down syndrome and Ets transcription factors, respectively, obtaining the first evidence for an intra-chromosomal regulatory loop on chromosome 21 involving Ets2 (3 papers), and revealing the role of p53 in immune-suppression in Down syndrome (Hum Mol. Genetics). He then joined Prof Martin Pera in the Australian Stem Cell Centre in 2003 to pioneer human embryonic stem cell research in Australia, resulting in a first author Nature Biotechnology paper in 2006 identifying CD30 as a marker for genetically abnormal hESC (72 cites). He was appointed group leader of the Basic human stem cell biology laboratory in the ASCC research laboratory and senior lecturer in the Department of Anatomy and Cell biology until he accepted his current position as an independent group leader at the AIBN and Professor in stem cell biology at the University of Queensland in 2008. There he started to generate integration-free induced pluripotent stem cells from human neurological diseases such as ataxia-telangiectasia (Stem cells translational medicine). In recognition of his leadership role in this area of research he was appointed leader of the "Reprogramming and Induction of pluripotency" Collaborative Stream of the Australian Stem Cell Centre until the end of that initiative in 2011, coordinating collaborative research between eight stem cell laboratories across Australia. He subsequently initiated and is now the president of Cell Reprogramming Australia, a collaborative framework aiming to facilitate and accelerate iPS cell research in Australia and the Asia pacific region and inform the general public about reprogramming technology. His research continues to combine cell reprogramming technology, genome editing/analysis tools and microfluidic/nanoparticle based detection/ delivery technologies with the aim of creating human in vitro models of disease, unravel the underlying gene regulatory networks and enable novel cell- and delivery-based therapeutics, respectively. He further co-direct the UQ-Centre for stem cell ageing and regenerative engineering (UQ-StemCARE).

Publications

Book Chapters (4)

Journal Articles (197)

Conference Papers (26)

Preprint (1)

Research Report (1)

Book Chapters

Nayler, Sam, Kozlov, Sergei V., Lavin, Martin F. and Wolvetang, Ernst (2017). Lentiviral reprogramming of A-T patient fibroblasts to induced pluripotent stem cells. In Sergei V. Kozlov (Ed.), ATM kinase: methods and protocols (pp. 401-418) New York, NY, United States: Humana Press; Springer Science+Business Media. doi:10.1007/978-1-4939-6955-5_29

Thakar, Nilay Y. and Wolvetang, Ernst J. (2015). Ascorbate as a modulator of the epigenome. Nutrition and epigenetics. (pp. 199-218) edited by Emily Ho and Frederick Domann. Boca Raton, FL, United States: CRC Press. doi: 10.1201/b17530-11

Frith, Jessica E., Jaramillo-Ferrada, Pamela, Mills, Richard J., Cameron, Andrew R., Titmarsh, Drew M., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Development of defined culture conditions for expansion of human mesenchymal stromal cells for clinical applications. Stem cells and cancer stem cells: therapeutic applications in disease and injury. (pp. 13-26) edited by M. A. Hayat. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-007-4798-2_2

Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2011). Smads: The intracellular hubs of signalling in regulation of pluripotency and differentiation of stem cells. Embryonic stem cells: The hormonal regulation of pluripotency and embryogenesis. (pp. 191-216) edited by Craig Atwood. Vienna, Austria: Intech Open Access.

Journal Articles

Al-mhanawi, Bahaa, Marti, Marta Boira, Morrison, Sean D., Gupta, Pallavi, Alani, Maath, Noakes, Peter G., Wolvetang, Ernst J. and Shaker, Mohammed R. (2023). Protocol for generating embedding-free brain organoids enriched with oligodendrocytes. STAR Protocols, 4 (4) 102725, 102725. doi: 10.1016/j.xpro.2023.102725

Tabassum, Tahmina, Pietrogrande, Giovanni, Healy, Michael and Wolvetang, Ernst J. (2023). CRISPR-Cas9 Direct Fusions for Improved Genome Editing via Enhanced Homologous Recombination. International Journal of Molecular Sciences, 24 (19) 14701, 14701. doi: 10.3390/ijms241914701

Tracey, Timothy J., Jiang, Leanne, Gill, Melinder K., Ranie, Samara N., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Ngo, Shyuan T. (2023). Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation. Stem Cell Research, 70 103137, 1-6. doi: 10.1016/j.scr.2023.103137

Taherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 1-17. doi: 10.1007/s11357-023-00829-y

Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv. doi: 10.1101/2023.06.12.544552

Peng, Lianli, Baradar, Alireza A., Aguado, Julio and Wolvetang, Ernst (2023). Cellular senescence and premature aging in Down Syndrome. Mechanisms of Ageing and Development, 212 111824, 1-9. doi: 10.1016/j.mad.2023.111824

Martin, Sally, Poppe, Daniel, Olova, Nelly, O’Leary, Conor, Ivanova, Elena, Pflueger, Jahnvi, Dechka, Jennifer, Simmons, Rebecca K., Cooper, Helen M., Reik, Wolf, Lister, Ryan and Wolvetang, Ernst J. (2023). Embryonic stem cell-derived neurons as a model system for epigenome maturation during development. Genes, 14 (5) 957. doi: 10.3390/genes14050957

Slonchak, Andrii, Chaggar, Harman, Aguado, Julio, Wolvetang, Ernst and Khromykh, Alexander A. (2023). Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissue. Viruses, 15 (5) 1062, 1062. doi: 10.3390/v15051062

Noakes, Peter G., Phillips, William D., Jeffree, Rosalind L., Steyn, Frederik J., Wolvetang, Ernst J., Henderson, Rob D., McCombe, Pamela A. and Ngo, Shyuan T. (2023). Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease. Journal of Experimental Neurology, 4 (1), 1-5. doi: 10.33696/neurol.4.067

He, Chang-Long, Tang, Yong, Chen, Xue, Long, Tao, He, Yan-Ni, Wei, Jing, Wu, Jian-Ming, Lan, Cai, Yu, Lu, Huang, Fei-Hong, Gu, Cong-Wei, Liu, Jian, Yu, Chong-Lin, Wong, Vincent Kam-Wai, Law, Betty Yuen-Kwan, Qin, Da-Lian, Wu, An-Guo and Zhou, Xiao-Gang (2023). Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases. Phytomedicine, 109 ARTN 154548, 154548. doi: 10.1016/j.phymed.2022.154548

Ribaudo, Giovanni, Yun, Xiaoyun, Ongaro, Alberto, Oselladore, Erika, Ng, Jerome P. L., Haynes, Richard K., Law, Betty Yuen Kwan, Memo, Maurizio, Wong, Vincent Kam Wai, Coghi, Paolo and Gianoncelli, Alessandra (2022). Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study. Chemical Biology & Drug Design, 101 (4), 809-818. doi: 10.1111/cbdd.14187

Slonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D. J., Chaggar, Harman, Freney, Morgan E., Yan, Kexin, Torres, Francisco J., Amarilla, Alberto A., Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas and Khromykh, Alexander A. (2022). Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis. Science Advances, 8 (48) eadd8095, eadd8095. doi: 10.1126/sciadv.add8095

Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y

Yin, Lin, Huang, Guoxin, Khan, Imran, Su, Lu, Xia, Wenrui, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai, Wu, Qiang, Wang, Jingyi, Leong, Wai Kit and Hsiao, W. L. Wendy (2022). Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in Apc^Min/+ mice. Chinese Medicine, 17 (1) ARTN 116. doi: 10.1186/s13020-022-00667-8

Leeson, Hannah C., Goh, Denise, Coman, David and Wolvetang, Ernst J. (2022). Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutations. Stem Cell Research, 64 102917, 1-5. doi: 10.1016/j.scr.2022.102917

Wu, Kaiyuan, Takanohashi, Asako, Woidill, Sarah, Seylani, Allen, Helman, Guy, Dias, Patricia, Beers, Jeanette, Lin, Yongshun, Simons, Cas, Wolvetang, Ernst, Zou, Jizhong, Vanderver, Adeline and Sack, Michael N. (2022). Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutations. Stem Cell Research, 64 102905, 1-6. doi: 10.1016/j.scr.2022.102905

Aguado, Julio, Gómez-Inclán, Cecilia, Leeson, Hannah C., Lavin, Martin F., Shiloh, Yosef and Wolvetang, Ernst J. (2022). The hallmarks of aging in ataxia-telangiectasia. Ageing Research Reviews, 79 101653, 1-15. doi: 10.1016/j.arr.2022.101653

Isaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262

Shaker, Mohammed R., Hunter, Zoe L. and Wolvetang, Ernst J. (2022). Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitro. Journal of Visualized Experiments, 2022 (183) e63714. doi: 10.3791/63714

Gao, Zhenxiong, Fan, Tingting, Chen, Linbo, Yang, Mengchu, Wong, Vincent Kam Wai, Chen, Dawei, Liu, Zijian, Zhou, Yaoyao, Wu, Weibin, Qiu, Zixuan, Zhang, Cunlong, Li, Yuan and Jiang, Yuyang (2022). Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3? protein. European Journal of Medicinal Chemistry, 238 ARTN 114402. doi: 10.1016/j.ejmech.2022.114402

Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5

Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2022). Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening. Stem Cell Research, 60 102673, 102673. doi: 10.1016/j.scr.2022.102673

Aguado, Julio and Wolvetang, Ernst J (2022). Exploring aging interventions in human brain organoids. Aging, 14 (4), 1592-1593. doi: 10.18632/aging.203925

Shaker, Mohammed R., Kahtan, Amna, Prasad, Renuka, Lee, Ju-Hyun, Pietrogrande, Giovanni, Leeson, Hannah C., Sun, Woong, Wolvetang, Ernst J. and Slonchak, Andrii (2022). Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types. Frontiers in Cell and Developmental Biology, 10 803061, 803061. doi: 10.3389/fcell.2022.803061

Mahmoud, Nuha, Dawood, Mona, Huang, Qi, Ng, Jerome P. L., Ren, Fang, Wong, Vincent K. W. and Efferth, Thomas (2021). Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growth. Phytomedicine, 94 ARTN 153826, 153826. doi: 10.1016/j.phymed.2021.153826

Leeson, Hannah C., Hunter, Zoe, Chaggar, Harman Kaur, Lavin, Martin F., Mackay-Sim, Alan and Wolvetang, Ernst J. (2021). Ataxia Telangiectasia iPSC line generated from a patient olfactory biopsy identifies novel disease-causing mutations. Stem Cell Research, 56 102528, 102528. doi: 10.1016/j.scr.2021.102528

Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2021). Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients. Stem Cell Research, 56 102564, 102564. doi: 10.1016/j.scr.2021.102564

Leeson, Hannah C., Hunter, Zoe, Chaggar, Harman Kaur, Mackay-Sim, Alan and Wolvetang, Ernst J. (2021). Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort. Stem Cell Research, 56 102527, 102527. doi: 10.1016/j.scr.2021.102527

Aguado, Julio, Chaggar, Harman K., Gómez‐Inclán, Cecilia, Shaker, Mohammed R., Leeson, Hannah C., Mackay‐Sim, Alan and Wolvetang, Ernst J. (2021). Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids. Aging Cell, 20 (9) e13468, 1-16. doi: 10.1111/acel.13468

Shaker, Mohammed R., Aguado, Julio, Chaggar, Harman Kaur and Wolvetang, Ernst J. (2021). Klotho inhibits neuronal senescence in human brain organoids. npj Aging and Mechanisms of Disease, 7 (1) 18, 1-12. doi: 10.1038/s41514-021-00070-x

Ding, Qiao, Chaplin, Justin, Morris, Matthew J., Hilliard, Massimo A., Wolvetang, Ernst, Ng, Dominic C. H. and Noakes, Peter G. (2021). TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells. Frontiers in Cell and Developmental Biology, 9 611601, 611601. doi: 10.3389/fcell.2021.611601

Alharbi, Samah Abdulaali, Ovchinnikov, Dmitry A. and Wolvetang, Ernst (2021). Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines. World Journal of Gastroenterology, 27 (15), 1578-1594. doi: 10.3748/WJG.V27.I15.1578

Shaker, Mohammed R., Pietrogrande, Giovanni, Martin, Sally, Lee, Ju-Hyun, Woong, Sun and Wolvetang, Ernst J. (2021). Rapid and efficient generation of myelinating human oligodendrocytes in organoids. Frontiers in Cellular Neuroscience, 15 631548, 1-11. doi: 10.3389/fncel.2021.631548

Chepkirui, Carolyne, Ochieng, Purity J., Sarkar, Biswajyoti, Hussain, Aabid, Pal, Chiranjib, Yang, Li Jun, Coghi, Paolo, Akala, Hoseah M., Derese, Solomon, Ndakala, Albert, Heydenreich, Matthias, Wong, Vincent K. W., Erdelyi, Mate and Yenesew, Abiy (2021). Antiplasmodial and antileishmanial flavonoids from Mundulea sericea. Fitoterapia, 149 ARTN 104796. doi: 10.1016/j.fitote.2020.104796

Yeo, Abrey J., Kok, Chong L., Gatei, Magtouf, Zou, Dongxiu, Stewart, Romal, Withey, Sarah, Wolvetang, Ernst, Parton, Robert G., Brown, Adam D., Kastan, Michael B., Coman, David and Lavin, Martin F. (2021). Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia. iScience, 24 (1) 101972, 101972. doi: 10.1016/j.isci.2020.101972

Ankeny, Rachel A. and Wolvetang, Ernst (2021). Testing the correlates of consciousness in brain organoids: how do we know and what do we do?. The American Journal of Bioethics, 21 (1), 51-53. doi: 10.1080/15265161.2020.1845869

Tursky, Melinda L., Loi, To Ha, Artuz, Crisbel M., Alateeq, Suad, Wolvetang, Ernst J., Tao, Helen, Ma, David D. and Molloy, Timothy J. (2020). Direct comparison of four hematopoietic differentiation methods from human induced pluripotent stem cells. Stem Cell Reports, 15 (3), 735-748. doi: 10.1016/j.stemcr.2020.07.009

Aguado, Julio, d’Adda di Fagagna, Fabrizio and Wolvetang, Ernst (2020). Telomere transcription in Ageing. Ageing Research Reviews, 62 101115, 101115. doi: 10.1016/j.arr.2020.101115

Yaremenko, Ivan A., Coghi, Paolo, Prommana, Parichat, Qiu, Congling, Radulov, Peter S., Qu, Yuanqing, Belyakova, Yulia Yu., Zanforlin, Enrico, Kokorekin, Vladimir A., Wu, Yuki Yu Jun, Fleury, Fabrice, Uthaipibull, Chairat, Wong, Vincent Kam Wai and Terent'ev, Alexander O. (2020). Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P-Glycoprotein ABCB5. Chemmedchem, 15 (13), 1118-1127. doi: 10.1002/cmdc.202000042

Tao, Na-Na, Zhang, Zhen-Zhen, Ren, Ji-Hua, Zhang, Juan, Zhou, Yu-Jiao, Wong, Vincent Kam Wai, Law, Betty Yuen Kwan, Cheng, Sheng-Tao, Zhou, Hong-Zhong, Chen, Wei-Xian, Xu, Hong-Mei and Chen, Juan (2020). Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway. Cancer Letters, 481, 1-14. doi: 10.1016/j.canlet.2020.03.028

Hollywood, Jennifer A., Przepiorski, Aneta, D'Souza, Randall F., Sreebhavan, Sreevalsan, Wolvetang, Ernst J., Harrison, Patrick T., Davidson, Alan J. and Holm, Teresa M. (2020). Use of human induced pluripotent stem cells and kidney organoids to develop a cysteamine/mTOR inhibition combination therapy for cystinosis. Journal of the American Society of Nephrology , 31 (5), 962-982. doi: 10.1681/ASN.2019070712

Ovchinnikov, Dmitry A., Withey, Sarah L., Leeson, Hannah C., Lei, U. Wang, Sundarrajan, Ashmitha, Junday, Keerat, Pewarchuk, Michelle, Yeo, Abrey J., Kijas, Amanda W., Lavin, Martin F. and Wolvetang, Ernst J. (2020). Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses. Human Molecular Genetics, 29 (6), 990-1001. doi: 10.1093/hmg/ddaa023

Weeratunga, Prasanna, Shahsavari, Arash, Fennis, Evelien, Wolvetang, Ernst J., Ovchinnikov, Dmitry A. and Whitworth, Deanne J. (2020). Induced pluripotent stem cell-derived mesenchymal stem cells from the Tasmanian devil (Sarcophilus harrisii) express immunomodulatory factors and a tropism toward devil facial tumor cells. Stem Cells and Development, 29 (1), 25-37. doi: 10.1089/scd.2019.0203

Glass, Nick R., Takasako, Minoru, Er, Pei Xuan, Titmarsh, Drew M., Hidalgo, Alejandro, Wolvetang, Ernst J., Little, Melissa H. and Cooper-White, Justin J. (2020). Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development. Science Advances, 6 (2) eaaw2746, 1-13. doi: 10.1126/sciadv.aaw2746

Huang, Bixing, West, Nic, Vider, Jelena, Zhang, Ping, Griffiths, Rebecca E., Wolvetang, Ernst, Burtonclay, Peter and Warrilow, David (2019). Inflammatory responses to a pathogenic West Nile virus strain. BMC Infectious Diseases, 19 (1) 912, 912. doi: 10.1186/s12879-019-4471-8

Setoh, Yin Xiang, Amarilla, Alberto A., Peng, Nias Y. G., Griffiths, Rebecca E., Carrera, Julio, Freney, Morgan E., Nakayama, Eri, Ogawa, Shinya, Watterson, Daniel, Modhiran, Naphak, Nanyonga, Faith Elizabeth, Torres, Francisco J., Slonchak, Andrii, Periasamy, Parthiban, Prow, Natalie A., Tang, Bing, Harrison, Jessica, Hobson-Peters, Jody, Cuddihy, Thom, Cooper-White, Justin, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Wolvetang, Ernst, Bloom, Jesse D., Suhrbier, Andreas and Khromykh, Alexander A. (2019). Determinants of Zika virus host tropism uncovered by deep mutational scanning. Nature Microbiology, 4 (5), 876-887. doi: 10.1038/s41564-019-0399-4

Salvador-Palomeque, Carmen, Sanchez-Luque, Francisco J., Fortuna, Patrick R. J., Ewing, Adam D., Wolvetang, Ernst J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2019). Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation. Molecular and Cellular Biology, 39 (7) e00499-18, 1-19. doi: 10.1128/mcb.00499-18

Kessel, Stefanie, Thakar, Nilay, Jia, Zhongfan, Wolvetang, Ernst J. and Monteiro, Michael J. (2019). GRGD-decorated three-dimensional nanoworm hydrogels for culturing human embryonic stem cells. Journal of Polymer Science Part A: Polymer Chemistry, 57 (18), 1956-1963. doi: 10.1002/pola.29342

Whitworth, Deanne J., Limnios, Ioannis J., Gauthier, Marie-Emilie, Weeratunga, Prasanna, Ovchinnikov, Dmitry A., Baillie, Gregory, Grimmond, Sean M., Graves, Jennifer A. Marshall and Wolvetang, Ernst J. (2019). Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme. Stem Cells and Development, 28 (3), 151-164. doi: 10.1089/scd.2018.0179

Requena, J., Alvarez-Palomo, A. B., Codina-Pascual, M., Delgado-Morales, R., Moran, S., Esteller, M., Sal, M., Juan, M., Boronat Barado, A., Consiglio, A., Bogle, O. A., Wolvetang, E., Ovchinnikov, D., Alvarez, I., Jaraquemada, D., Mezquita-Pla, J., Oliva, R. and Edel, M. J. (2019). Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signaling. Stem Cells, 37 (4), 476-488. doi: 10.1002/stem.2966

Phipson, Belinda, Er, Pei X., Combes, Alexander N., Forbes, Thomas A., Howden, Sara E., Zappia, Luke, Yen, Hsan-Jan, Lawlor, Kynan T., Hale, Lorna J., Sun, Jane, Wolvetang, Ernst, Takasato, Minoru, Oshlack, Alicia and Little, Melissa H. (2018). Evaluation of variability in human kidney organoids. Nature Methods, 16 (1), 79-87. doi: 10.1038/s41592-018-0253-2

Alateeq, Suad, Ovchinnikov, Dmitry, Tracey, Timothy, Whitworth, Deanne, Al-Rubaish, Abdullah, Al-Ali, Amein and Wolvetang, Ernst (2018). Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. APL Bioengineering, 2 (4) 046103, 046103. doi: 10.1063/1.5048625

Yaouba, Souaibou, Valkonen, Arto, Coghi, Paolo, Gao, Jiaying, Guantai, Eric M., Derese, Solomon, Wong, Vincent K. W., Erdelyi, Mate and Yenesew, Abiy (2018). Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species. Molecules, 23 (12) ARTN 3199, 3199. doi: 10.3390/molecules23123199

Homan, Claire C., Pederson, Stephen, To, Thu-Hien, Tan, Chuan, Piltz, Sandra, Corbett, Mark, Wolvetang, Ernst, Thomas, Paul, Jolly, Lachlan A. and Gecz, Jozef (2018). PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy. Neurobiology of Disease, 116, 106-119. doi: 10.1016/j.nbd.2018.05.004

Przepiorski, Aneta, Sander, Veronika, Tran, Tracy, Hollywood, Jennifer A., Sorrenson, Brie, Shih, Jen-Hsing, Wolvetang, Ernst J., McMahon, Andrew P., Holm, Teresa M. and Davidson, Alan J. (2018). A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells. Stem Cell Reports, 11 (2), 470-484. doi: 10.1016/j.stemcr.2018.06.018

Ovchinnikov, Dmitry A., Korn, Othmar, Virshup, Isaac, Wells, Christine A. and Wolvetang, Ernst J. (2018). The impact of APP on Alzheimer-like pathogenesis and gene expression in Down syndrome iPSC-derived neurons. Stem Cell Reports, 11 (1), 32-42. doi: 10.1016/j.stemcr.2018.05.004

Hidalgo, Alejandro, Glass, Nick, Ovchinnikov, Dmitry, Yang, Seung-Kwon, Zhang, Xinli, Mazzone, Stuart, Chen, Chen, Wolvetang, Ernst and Cooper-White, Justin (2018). Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes. APL Bioengineering, 2 (2) 026102, 026102. doi: 10.1063/1.5000746

Fortuna, Patrick R. J., Bielefeldt-Ohmann, Helle, Ovchinnikov, Dmitry A., Wolvetang, Ernst Jurgen and Whitworth, Deanne Jeanette (2018). Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases. Stem Cells and Development, 27 (10), 704-715. doi: 10.1089/scd.2017.0106

Frohlich, Dominik, Suchowerska, Alexandra K., Voss, Carola, He, Ruojie, Wolvetang, Ernst, von Jonquieres, Georg, Simon, Cas, Fath, Thomas, Housley, Gary D. and Klugmann, Matthias (2018). Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain. Frontiers in Molecular Neuroscience, 11 81, 81. doi: 10.3389/fnmol.2018.00081

Tracey, Timothy J., Steyn, Frederik J., Wolvetang, Ernst J. and Ngo, Shyuan T. (2018). Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience, 11 10, 10. doi: 10.3389/fnmol.2018.00010

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Whitworth, Deanne J. (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Stem Cells and Development, 27 (2), 112-122. doi: 10.1089/scd.2017.0224

Ng, Gervase, Yeow, Jonathan, Chapman, Robert, Isahak, Naatasha, Wolvetang, Ernst, Cooper-White, Justin J. and Boyer, Cyrille (2018). Pushing the Limits of High Throughput PET-RAFT Polymerization. Macromolecules, 51 (19), 7600-7607. doi: 10.1021/acs.macromol.8b01600

Wong, Li-Yen, Xia, Bingzhao, Wolvetang, Ernst and Cooper-White, Justin J. (2017). Targeted, stimuli-responsive delivery of plasmid DNA and miRNAs using a facile self-assembled supramolecular nanoparticle system. Biomacromolecules, 19 (2), 353-363. doi: 10.1021/acs.biomac.7b01462

Nayler, Sam P., Powell, Joseph E., Vanichkina, Darya P., Korn, Othmar, Wells, Christine A., Kanjhan, Refik, Sun, Jian, Taft, Ryan J., Lavin, Martin F. and Wolvetang, Ernst J. (2017). Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks. Frontiers in Cellular Neuroscience, 11 321, 321. doi: 10.3389/fncel.2017.00321

Bellmaine, Stephanie F., Ovchinnikov, Dmitry A., Manallack, David T., Cuddy, Claire E., Elefanty, Andrew G., Stanley, Edouard G., Wolvetang, Ernst J., Williams, Spencer J. and Pera, Martin (2017). Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. Elife, 6 e24502. doi: 10.7554/eLife.24502

Hawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015

Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112

Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017

Kao, L. P. and Wolvetang, E. J. (2017). Mitochondrial dysfunction and mitophagy in neurodegenerative diseases. Cell and Developmental Biology, 6 doi: 10.4172/2168-9296.1000184

Vitale, Alejandra M., Matigian, Nicholas A., Cristino, Alexandre S., Nones, Katia, Ravishankar, Sugandha, Bellette, Bernadette, Fan, Yongjun, Wood, Stephen A., Wolvetang, Ernst and Mackay-Sim, Alan (2017). DNA methylation in schizophrenia in different patient-derived cell types. Schizophrenia, 3 (1) 6, 1-11. doi: 10.1038/s41537-016-0006-0

Lavin, Martin F., Yeo, Abrey J., Kijas, Amanda W., Wolvetang, Ernst, Sly, Peter D., Wainwright, Claire and Sinclair, Kate (2016). Therapeutic targets and investigated treatments for Ataxia-Telangiectasia. Expert Opinion on Orphan Drugs, 4 (12), 1263-1276. doi: 10.1080/21678707.2016.1254618

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 (4), 927-947. doi: 10.1189/jlb.4VMA0716-316R

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371

Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., Lopes, Susana M. Chuva de Sousa and Little, Melissa H. (2016). Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 536 (7615), 238-238. doi: 10.1038/nature17982

Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. Plos One, 11 (7) e0160162, e0160162. doi: 10.1371/journal.pone.0160162

Titmarsh, Drew M., Glass, Nick R., Mills, Richard J., Hidalgo, Alejandro, Wolvetang, Ernst J., Porrello, Enzo R., Hudson, James E. and Cooper-White, Justin J. (2016). Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays. Scientific Reports, 6 (1) 24637, 24637. doi: 10.1038/srep24637

Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. PLoS One, 11 (2) e0148213, e0148213. doi: 10.1371/journal.pone.0148213

Klionsky, Daniel J., et al., Wolvetang, Ernst and Walker, Mark J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi: 10.1080/15548627.2015.1100356

Klawitter, Sabine, Fuchs,Nina V., Upton, Kyle R., Munoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Merkert, Sylvia, Gerdes, Patricia, Pulgarin, J. Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Sarkadi, Balazs, Lower, Johannes, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltan, Izsvak, Zsuzsanna, Garcia-Perez, Jose L., Faulkner, Geoffrey J. and Schumann, Gerald G. (2016). Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature Communications, 7 (1) 10286, 1-14. doi: 10.1038/ncomms10286

Kliosnky, D., Ernst Wolvetang and Mark J. Walker (2016). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015). Autophagy, 12 (2), 443-443. doi: 10.1080/15548627.2016.1147886

Ovchinnikov, Dmitry A., Sun, Jane and Wolvetang, Ernst J. (2015). Generation of footprint-free induced pluripotent stem cells from human fibroblasts using episomal plasmid vectors. Methods in Molecular Biology, 1330, 37-45. doi: 10.1007/978-1-4939-2848-4_4

Briggs, James A., Wolvetang, Ernst J., Mattick, John S., Rinn, John L. and Barry, Guy (2015). Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron, 88 (5), 861-877. doi: 10.1016/j.neuron.2015.09.045

Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., de Sousa Lopes, Susana M. Chuva and Little, Melissa H. (2015). Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 526 (7574), 564-568. doi: 10.1038/nature15695

Mallett, Andrew, Patel, Chirag, Maier, Barbara, McGaughran, Julie, Gabbett, Michael, Takasato, Minoru, Cameron, Anne, Trnka, Peter, Alexander, Stephen I., Rangan, Gopala, Tchan, Michel C., Caruana, Georgina, John, George, Quinlan, Cathy, McCarthy, Hugh J., Hyland, Valentine, Hoy, Wedy E., Wolvetang, Ernst, Taft, Ryan, Simons, Cas, Healy H. and Little, Melissa (2015). A protocol for the identification and validation of novel genetic causes of kidney disease. BMC Nephrology, 16 (152) 148, 152. doi: 10.1186/s12882-015-0148-8

Hasegawa, Yu., Taylor, Deanne., Ovchinnikov, Dmitry A., Wolvetang, Ernst J., de Torrente, Laurence. and Mar, Jessica C. (2015). Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS Genetics, 11 (8) e1005428, e1005428. doi: 10.1371/journal.pgen.1005428

Becherel, Olivier J., Sun, Jane, Yeo, Abrey J., Nayler, Sam, Fogel, Brent L., Gao, Fuying, Coppola, Giovanni, Criscuolo, Chiara, De Michele, Giuseppe, Wolvetang, Ernst and Lavin, Martin F. (2015). A new model to study neurodegeneration in ataxia oculomotor apraxia type 2. Human Molecular Genetics, 24 (20), 5759-5774. doi: 10.1093/hmg/ddv296

Chen, Huaying, Sun, Jane, Wolvetang, Ernst and Cooper-White, Justin (2015). High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices. Lab on a Chip, 15 (4), 1072-1083. doi: 10.1039/C4LC01176G

Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290

Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754

Alateeq, Suad, Fortuna, Patrick R. J. and Wolvetang, Ernst (2015). Advances in reprogramming to pluripotency. Current Stem Cell Research and Therapy, 10 (3), 193-207. doi: 10.2174/1574888X10666150220154820

Dingwall, Steven, Brooks, Andrew, Apte, Simon H., Waters, Mike, Lavin, Martin F. and Wolvetang, Ernst J. (2015). Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance. Journal of Stem Cell Research and Therapy, 5 (12) 1000320, 1-8. doi: 10.4172/2157-7633.1000320

Liang, Cong, The FANTOM Consortium, Forrest, Alistair R. R., Wagner, Guenter P., Kenna, Tony, Beckhouse, Anthony, Blumenthal, Antje, Briggs, James, Hitchens, Kelly, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine and Wolvetang, Ernst (2015). The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nature Communications, 6 (1) 6066. doi: 10.1038/ncomms7066

Thakar, Nilay Yogeshkumar, Ovchinnikov, Dmitry Alexander, Hastie, Marcus Lachlan, Gorman, Jeffrey and Wolvetang, Ernst Jurgen (2015). RELB alters proliferation of human pluripotent stem cells via IMP3- and LIN28-mediated modulation of the expression of IGF2 and other cell-cycle regulators. Stem Cells and Development, 24 (16), 1888-1900. doi: 10.1089/scd.2014.0587

Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2014). Opportunities and limitations of modelling Alzheimer’s disease with induced pluripotent stem cells. Journal of Clinical Medicine, 3 (4), 1357-1372. doi: 10.3390/jcm3041357

Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014). Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 (12), 3278-3284. doi: 10.1002/stem.1801

Alamein, Mohammad A., Wolvetang, Ernst J., Ovchinnikov, Dmitry A., Stephens, Sebastien, Sanders, Katherine and Warnke, Patrick H. (2014). Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.. Journal of Tissue Engineering and Regenerative Medicine, 9 (9), 1078-1083. doi: 10.1002/term.1960

Turner, Jennifer, Quek,Lake-Ee, Titmarsh, Drew, Kromer, Jens O., Kao, Li-Pin, Nielsen, Lars, Wolvetang, Ernst and Cooper-White, Justin (2014). Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations. PLoS One, 9 (11) e112757, e112757.1-e112757.13. doi: 10.1371/journal.pone.0112757

Ovchinnikov, Dmitry A.,, Hidalgo, Alejandro, Yang, Seung-Kwon, Zhang, Xinli, Hudson, James, Mazzone, Stuart B., Chen, Chen, Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter. Stem Cells and Development, 24 (1), 11-20. doi: 10.1089/scd.2014.0195

Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 (2), 251-261. doi: 10.1016/j.scr.2014.05.006

Mason, Elizabeth, Mar, Jessica C., Laslett, Andrew, Pera, Martin F., Quackenbush, John, Wolvetang, Ernst and Wells C. (2014). Gene expression variability as a unifying element of the pluripotency network. Stem Cell Reports, 3 (2), 365-377. doi: 10.1016/j.stemcr.2014.06.008

Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print (24), 3021-3033. doi: 10.1089/scd.2013.0634

Hasegawa, Yuki, Tang, Dave, Takahashi, Naoko, Hayashizaki, Yoshihide, Forrest, Alistair R. R., the FANTOM consortium, Suzuki, Harukazu, Blumenthal, Antje, Kenna, Tony, Briggs, James, Beckhouse, Anthony G., Hitchens, Kelly J., Ovchinnikov, Dmitry A., Vijayan, Dipti, Wells, Christine A. and Wolvetang, Ernst (2014). CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes. Scientific Reports, 4 (Art No: 5228) 5228, 277-279. doi: 10.1038/srep05228

Schmidl, Christian, Hansmann, Leo, Lassmann, Timo, Balwierz, Piotr J., Kawaji, Hideya, Itoh, Masayoshi, Kawai, Jun, Nagao-Sato, Sayaka, Suzuki, Harukazu, Andreesen, Reinhard, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Carninci, Piero, Hoffmann, Petra, Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Wells, Christine and Wolvetang, Ernst (2014). The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood, 123 (17), e68-e78. doi: 10.1182/blood-2013-02-486944

Prasad, Punit, Rönnerblad, Michelle, Arner, Erik, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Daub, Carsten O., Forrest, Alistair R. R., Lennartsson, Andreas, Ekwall, Karl, for the FANTOM Consortium, Wells, Christine, Wolvetang, Ernst, Blumenthal, Antje and Kenna, Tony (2014). High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis. Blood, 123 (17), e46-e57. doi: 10.1182/blood-2013-02-483537

Motakis, Efthymios, Guhl, Sven, Ishizu, Yuri, Itoh, Masayoshi, Kawaji, Hideya, de Hoon, Michiel, Lassman, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Zuberbier, Torsten, Forrest, Alistair R. R., Babina, Magda, for The FANTOM Consortium, Wells, Christine, Wolvetang, Ernst, Beckhouse, Anthony, Fearnley, Liam, Hitchens, Kelly, Kenna, Tony, Le Cao, Kim-Anh, Mason, Elizabeth, Nielsen, Lars, Vijayan, Dipti, Blumenthal, Antje, Ovchinnikov, Dmitry and Briggs, James (2014). Redefinition of the human mast cell transcriptome by deep-CAGE sequencing. Blood, 123 (17), 58-67. doi: 10.1182/blood-2013-02-483792

Severin, Jessica, Lizio, Marina, Harshbarger, Jayson, Kawaji, Hideya, Daub, Carsten O., Hayashizaki, Yoshihide, Bertin, Nicolas, Forrest, Alistair R. R., FANTOM Consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam and Kenna, Tony (2014). Interactive visualization and analysis of large-scale sequencing datasets using ZENBU. Nature Biotechnology, 32 (3), 217-219. doi: 10.1038/nbt.2840

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014). Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles (13), 1-9. doi: 10.1089/scd.2013.0461

Tomaru, Yasuhiro, Hasegawa, Ryota, Suzuki, Takahiro, Sato, Taiji, Kubosaki, Atsutaka, Suzuki, Masanori, Kawaji, Hideya, Forrest, Alistair R. R., Hayashizaki, Yoshihide, FANTOM Consortium, Shin, Jay W., Suzuki, Harukazu, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Fearnley, Liam, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014). A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation. Nucleic Acids Research, 42 (14), 8905-8913. doi: 10.1093/nar/gku567

Polanco, Juan Carlos, Ho, Mirabelle S. H., Wang, Bei, Zhou, Qi, Wolvetang, Ernst, Mason, Elizabeth, Wells, Christine A., Kolle, Gabriel, Grimmond, Sean M., Bertoncello, Ivan, O'Brien, Carmel and Laslett, Andrew L. (2013). Identification of Unsafe Human Induced Pluripotent Stem Cell Lines Using a Robust Surrogate Assay for Pluripotency. Stem Cells, 31 (8), 1498-1510. doi: 10.1002/stem.1425

Titmarsh, Drew M., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Cooper-White, Justin J. (2013). Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays. Biotechnology Journal, 8 (7), 822-834. doi: 10.1002/biot.201200375

Guan, Jun-Lin, Simon, Anna Katharina, Prescott, Mark, Menendez, Javier A., Liu, Fei, Wang, Fen, Wang, Chenran, Wolvetang, Ernst, Vazquez-Martin, Alejandro and Zhang, Jue (2013). Autophagy in stem cells. Autophagy, 9 (6), 830-849. doi: 10.4161/auto.24132

Briggs, James A., Sun, Jane, Shepherd, Jill, Ovchinnikov, Dmitry A., Chung, Tung-Liang, Nayler, Sam P., Kao, Li-Pin, Morrow, Carl A., Thakar, Nilay Y., Soo, Set-Yen, Peura, Teija, Grimmond, Sean and Wolvetang, Ernst J. (2013). Integration-free induced pluripotent stem cells model genetic and neural developmental features of Down Syndrome etiology. Stem Cells, 31 (3), 467-478. doi: 10.1002/stem.1297

Briggs, James A., Mason, Elizabeth A., Ovchinnikov, Dmitry A., Wells, Christine A. and Wolvetang, Ernst J. (2013). Concise review: new paradigms for down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Translational Medicine, 2 (3), 175-184. doi: 10.5966/sctm.2012-0117

Menzies, Donna J., Cameron, Andrew, Munro, Trent, Wolvetang, Ernst, Grondahl, Lisbeth and Cooper-White, Justin J. (2013). Tailorable cell culture platforms from enzymatically cross-linked multifunctional poly(ethylene glycol)-based hydrogels. Biomacromolecules, 14 (2), 413-423. doi: 10.1021/bm301652q

Titmarsh, Drew M., Chen, Huaying, Wolvetang, Ernst J. and Cooper-White, Justin J. (2013). Arrayed cellular environments for stem cells and regenerative medicine. Biotechnology Journal, 8 (2), 167-179. doi: 10.1002/biot.201200149

Filippich, Cheryl, Wolvetang, Ernst J. and Mowry, Bryan J. (2013). Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?. Schizophrenia Bulletin, 39 (5), 948-954. doi: 10.1093/schbul/sbt103

Barry, Guy, Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Vikram Ratnu, Nayler, S. P., Nones, K., Hu, J., Timothy Bredy, Nakagawa, S., Rigo, F., Taft, R. J., Cairns, M. J., Blackshaw, S., Wolvetang, E. J. and Mattick, J. S. (2013). The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molecular Psychiatry, 19 (4), 486-494. doi: 10.1038/mp.2013.45

Titmarsh, Drew M., Hudson, James E., Hidalgo, Alejandro, Elefanty, Andrew G., Stanley, Edouard G., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One, 7 (12) e52405, e52405.1-e52405.12. doi: 10.1371/journal.pone.0052405

Ovchinnikov, Dmitry A., Cooper, Matthew A., Pandit, Pratibala, Coman, William B., Cooper-White, Justin J., Keith, Patricia, Wolvetang, Ernst J., Slowey, Paul D. and Punyadeera, Chamindie (2012). Tumor-suppressor gene promoter hypermethylation in saliva of head and neck cancer patients. Translational Oncology, 5 (5), 321-326. doi: 10.1593/tlo.12232

Vitale, Alejandra M., Matigian, Nicholas A., Ravishankar, Sugandha, Bellette, Bernadette, Wood, Stephen A., Wolvetang, Ernst J. and Mackay-Sim, Alan (2012). Variability in the Generation of Induced Pluripotent Stem Cells: Importance for Disease Modeling. Stem Cells Translational Medicine, 1 (9), 641-650. doi: 10.5966/sctm.2012-0043

Jaramillo-Ferrada, Pamela A., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Differential mesengenic potential and expression of stem cell-fate modulators in mesenchymal stromal cells from human-term placenta and bone marrow. Journal of Cellular Physiology, 227 (9), 3234-3242. doi: 10.1002/jcp.24014

Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012). Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 (12), 2288-2297. doi: 10.1089/scd.2011.0608

Nayler, Sam, Gatei, Magtouf, Kozlov, Sergei, Gatti, Richard, Mar, Jessica C., Wells, Christine A., Lavin, Martin and Wolvetang, Ernst (2012). Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype. Stem Cells Translational Medicine, 1 (7), 523-535. doi: 10.5966/sctm.2012-0024

Ovchinnikov, Dmitry A., Turner, Jennifer P., Titmarsh, Drew M., Thakar, Nilay Y., Sin, Dong Choon, Cooper-White, Justin J. and Wolvetang, Ernst J. (2012). Generation of a human embryonic stem cell line stably expressing high levels of the fluorescent protein mCherry. World Journal of Stem Cells, 4 (7), 71-9. doi: 10.4252/wjsc.v4.i7.71

Hudson, James, Titmarsh, Drew, Hidalgo, Alejandro, Wolvetang, Ernst and Cooper-White, Justin (2012). Primitive cardiac cells from human embryonic stem cells. Stem Cells and Development, 21 (9), 1513-1523. doi: 10.1089/scd.2011.0254

Kao, Li-Pin, Ovchinnikov, Dmitry and Wolvetang, Ernst (2012). The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicology and Applied Pharmacology, 261 (1), 42-49. doi: 10.1016/j.taap.2012.03.009

Chen, Yen Shun, Pelekanos, Rebecca A., Ellis, Rebecca L., Horne, Rachel, Wolvetang, Ernst J. and Fisk, Nicholas M. (2012). Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells. Stem Cells Translational Medicine, 1 (2), 83-95. doi: 10.5966/sctm.2011-0022

Sin, Dongchoon, Fitzpatrick, Jane, Luckman, Paul, Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Fabrication of nanopatterned, porous microspheres using a glass capillary microfluidic device. Soft Matter, 8 (41), 10712-10718. doi: 10.1039/c2sm25950h

Titmarsh, Drew, Hidalgo, Alejandro, Turner, Jennifer, Wolvetang, Ernst and Cooper-White, Justin (2011). Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors. Biotechnology and Bioengineering, 108 (12), 2894-2904. doi: 10.1002/bit.23260

Tra, Thien, Gong, Lan, Kao, Lin-Pin, Li, Xue-Lei, Grandela, Catarina, Devenish, Rodney J., Wolvetang, Eernst and Prescott, Mark (2011). Autophagy in human embryonic stem cells. PLoS One, 6 (11) e27485, e27485.1-e27485.7. doi: 10.1371/journal.pone.0027485

Hudson, James E., Brooke, Gary, Blair, Chris, Wolvetang, Ernst and Cooper-White, Justin John (2011). Development of myocardial constructs using modulus-matched acrylated polypropylene glycol triol substrate and different nonmyocyte cell populations. Tissue Engineering Part A: Tissue Engineering, 17 (17-18), 2279-2289. doi: 10.1089/ten.tea.2010.0743

Hudson, James E., Mills, Richard J., Frith, Jessica E., Brooke, Gary, Jaramillo-Ferrada, Pamela, Wolvetang, Ernst J. and Cooper-White, Justin J. (2011). A defined medium and substrate for expansion of human mesenchymal stromal cell progenitors that enriches for osteo- and chondrogenic precursors. Stem Cells and Development, 20 (1), 77-87. doi: 10.1089/scd.2009.0497

Vitale, Alejandra M., Wolvetang, Ernst and Mackay-Sim, Alan (2011). Induced pluripotent cells: a new technology to study human diseases. The International Journal of Biochemistry and Cell Biology, In press (6), 843-846. doi: 10.1016/j.biocel.2011.03.013

Chung, Tung-Liang, Thaker, Nilay Y. and Wolvetang, Ernst J. (2011). Genetic and epigenetic instability of human pluripotent stem cells. The Open Stem Cell Journal, 3, 52-61. doi: 10.2174/1876893801103010052

Prowse, Andrew B. J., Doran, Michael R., Cooper-White, Justin J., Chong, Fenny, Munro, Trent P., Fitzpatrick, Jane, Chung, Tung-Liang, Haylock, David N., Gray, Peter P. and Wolvetang, Ernst J. (2010). Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials, 31 (32), 8281-8288. doi: 10.1016/j.biomaterials.2010.07.037

Hudson, James E., Frith, Jessica E., Donose, Bogdan C., Rondeau, Elisabeth, Mills, Richard J., Wolvetang, Ernst J., Brooke, Gary P. and Cooper-White, Justin J. (2010). A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications. Biomaterials, 31 (31), 7937-7947. doi: 10.1016/j.biomaterials.2010.07.007

Chung, Tung-Liang, Turner, Jennifer P., Thaker, Nilay Y., Kolle, Gabriel, Cooper-White, Justin J., Grimmond, Sean M., Pera, Martin F. and Wolvetang, Ernst J. (2010). Ascorbate promotes epigenetic activation of CD30 in human embryonic stem cells. Stem Cells, 28 (10), 1782-1793. doi: 10.1002/stem.500

Chung, TL, Brena, RM, Kolle, G, Grimmond, SM, Berman, BP, Laird, PW, Pera, MF and Wolvetang, EJ (2010). Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells, 28 (10), 1848-1855. doi: 10.1002/stem.493

Doran, Michael R., Frith, Jessica E., Prowse, Andrew B. J., Fitzpatrick, Jane, Wolvetang, Ernst J., Munro, Trent P., Gray, Peter P. and Cooper-White, Justin J. (2010). Defined high protein content surfaces for stem cell culture. Biomaterials, 31 (19), 5137-5142. doi: 10.1016/j.biomaterials.2010.03.015

Prowse, ABJ, Wilson, J, Osborne, GW, Gray, PP and Wolvetang, EJ (2009). Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers. Stem Cells and Development, 18 (8), 1135-1139. doi: 10.1089/scd.2009.0080

Hannan, N.R.F., Jamshidi, P., Pera, M.F. and Wolvetang, E.J. (2009). BMP-11 and Myostatin Support Undifferentiated Growth of Human Embryonic Stem Cells in Feeder-Free Cultures. Cloning and Stem Cells, 11 (3), 427-435. doi: 10.1089/clo.2009.0024

Grandela, C., Pera, M. F., Grimmond, S. M., Kolle, G. and Wolvetang, E. J. (2009). Corrigendum to "p53 is required for etoposide-induced apoptosis of human embryonic stem cells" [Stem Cell Research 1 (2008) 116-128]. Stem Cell Research, 3 (2-3), 179-179. doi: 10.1016/j.scr.2008.12.001

Prowse, ABJ, Wolvetang, EJ and Gray, PP (2009). A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps. Biotechniques, 47 (1), 599-606. doi: 10.2144/000113151

Hannan, Nicholas R.F. and Wolvetang, Ernst J. (2009). Adipocyte differentiation in human embryonic stem cells transduced with Oct4 shRNA lentivirus. Stem Cells Development, 18 (4), 653-660. doi: 10.1089/scd.2008.0160

Cullinane, Meabh, Gong, Lan, Lazar-Adler, Natalie, Tra, Thien, Wolvetang, Ernst, Prescott, Mark, Boyce, John D., Devenish, Rodney J. and Adler, Ben (2008). Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines. Autophagy, 4 (6), 744-753. doi: 10.4161/auto.6246

Grandela, C., Pera, M. F. and Wolvetang, E. J. (2008). p53 is required for etoposide-induced apoptosis of human embryonic stem cells. Stem Cell Research, 1 (2), 116-128. doi: 10.1016/j.scr.2007.10.003

Wolvetang, Ernst J., Pera, Martin F. and Zuckerman, Kenneth S. (2007). Gap junction mediated transport of shRNA between human embryonic stem cells. Biochemical and biophysical research communications, 363 (3), 610-615. doi: 10.1016/j.bbrc.2007.09.035

Grandela, C. and Wolvetang, E. (2007). hESC Adaptation, Selection and Stability. Stem Cell Reviews and Reports, 3 (3), 183-191. doi: 10.1007/s12015-007-0008-4

Herszfeld, Daniella, Wolvetang, Ernst, Langton-Bunker, Emma, Chung, Tung-Liang, Filipczyk, Adam A,, Houssami, Souheir, Pegah Jamshid, Koh, Karen, Laslett, Andrew L., Anna Michalska, Nguyen, Linh, Reubinoff, Benjamin E., Tellis, Irene, Auerbach, Jonathan M., Ording, Carol J., Looijenga, Leendert H. J. and Pera, Martin F. (2006). CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nature Biotechnology, 24 (3), 351-357. doi: 10.1038/nbt1197

Thouas, GA, Trounson, AO, Wolvetang, EJ and Jones, GM (2005). Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro. (vol 71, pg 1936, 2004). Biology of Reproduction, 73 (6), 1312-1312. doi: 10.1095/biolreprod.105.048561

Pebay, Alice, Wong, Raymond C. B., Pitson, Stuart M., Wolvetang, Ernst J., Peh, Gary S.-L., Fykilipcz, Adam, Koh, Karen L. L., Tellis, Irene, Nguyen, Linh T.V. and Pera, Martin F. (2005). Essential Roles of Sphingosine-1-Phosphate and Platelet-Derived Growth Factor in the Maintenance of Human Embryonic Stem Cells. Stem Cells, 23 (10), 1541-1548. doi: 10.1634/stemcells.2004-0338

Helguera, Pablo, Pelsman, Alejandra, Pigino, Gustavo, Wolvetang, Ernst, Head, Elizabeth and Busciglio, Jorge (2005). ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. Journal of Neuroscience, 25 (9), 2295-2303. doi: 10.1523/JNEUROSCI.5107-04.2005

Thouas, George, A., Trounson, Alan O., Wolvetang, Ernst J. and Jones, Gayle M. (2004). Mitochondrial Dysfunction in Mouse Oocytes Results in Preimplantation Embryo Arrest in Vitro full access. Biology of Reproduction, 71 (6), 1936-1942. doi: 10.1095/biolreprod.104.033589

Wolvetang, E. W., Bradfield, O. M., Tymms, M., Zavarsek, S., Hatzistavrou, T., Kola, I. and Hertzog, P. J. (2003). The chromosome 21 transcription factor ETS2 transactivates the β-APP promoter: Implications for Down syndrome. Biochimica et biophysica acta (BBA). Gene structure and expression, 1628 (2), 105-110. doi: 10.1016/S0167-4781(03)00121-0

Ohtani, Naoko, Brennan, Paul, Gaubatz, Stefan, Sanij, Elaine, Hertzog, Paul, Wolvetang, Ernst, Ghysdael, Jacques, Rowe, Martin and Hara, Eiji (2003). Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5. Journal of Cell Biology, 162 (2), 173-183. doi: 10.1083/jcb.200302085

Leech, Michelle, Lacey, Derek, Santos, leilani, Hutchinson, Paul, Wolvetang, Ernst, David, John R., Bucala, Richard and Morand, Eric F. (2003). Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis & Rheumatism, 48 (7), 1881-1889. doi: 10.1002/art.11165

Sanij, Elaine, Scott, Bernadette, Wilson, Trevor, Xu, Dakang, Hertzog, Paul and Wolvetang, Ernst (2003). Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein. Immunology Letters, 86 (1), 63-70. doi: 10.1016/S0165-2478(02)00258-4

Wolvetang, E. J., Wilson, T. J., Sanij, E., Busciglio, J., Hatzistavrou, T., Hertzog, P. J. and Kola, I. (2003). ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human Molecular Genetics, 12 (3), 247-255. doi: 10.1093/hmg/ddg015

Wolvetang, E. J., Bradfield, O. M., Hatzistavrou, T., Crack, P. J., Busciglio, J., Kola, I. and Hertzog, P. J. (2003). Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of Disease, 14 (3), 349-356. doi: 10.1016/S0969-9961(03)00107-4

Sanij, E., Hatzistavrou, T., Hertzog, P., Kola, I. and Wolvetang, E. J. (2002). Erratum: Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for down's syndrome, (Biochemical and Biophysical Research Communications (2001) 287:4 (1003-1008)). Biochemical and Biophysical Research Communications, 291 (1)

Sanij, E, Hatzistavrou, T, Hertzog, P, Kola, and Wolvetang, EJ (2002). Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's syndrome (vol 287, pg 1003, 2001). Biochemical and Biophysical Research Communications, 291 (1), 191-191. doi: 10.1006/bbrc.2002.6411

Sanij, E., Hatzistavrou, T., Hertzog, P., Kola, I. and Wolvetang, E. J. (2001). Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's Syndrome. Biochemical and Biophysical Research Communications, 287 (4), 1003-1008. doi: 10.1006/bbrc.2001.5680

Lacey, D. C., YH, Yang, Hutchinson, P,, Wolvetang, E,, Leech, M, and Morand, E. F. (2001). Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes. Arthritis and Rheumatism, 49 (4), S158-S158.

Hertzog, P. J., Pritchard, ., Wolvetang, E., Wilson, T., Owczarek, C. M. and Kola, I. (2001). Function of two gene families on human chromosome 21 and their potential contribution to Down syndrome. Cytogenetics and Cell Genetics, 92 (1-2), 12-12.

Lazner, F., Wolvetang, E. J., Lazner, D. and Hertzog, P. (2001). Bone disease: Current knowledge and future prospects. Current Genomics, 2 (2), 91-124. doi: 10.2174/1389202013351048

Bladier, C., Wolvetang, E. J., Hutchinson, P., de Haan, J. B. and Kola, I. (1997). Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?. Cell Growth and Differentiation, 8 (5), 589-598.

Bladier, C, Wolvetang, EJ, Hutchinson, P, deHaan, JB and Kola, I (1997). Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis. Cell Growth & Differentiation, 8 (5), 589-598.

Vaillant, F, Larm, JA, McMullen, GL, Wolvetang, EJ and Lawen, A (1996). Effecters of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators. Journal of Bioenergetics and Biomembranes, 28 (6), 531-540. doi: 10.1007/BF02110443

Wolvetang, EJ, Larm, JA, Moutsoulas, P and Lawen, A (1996). Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth & Differentiation, 7 (10), 1315-1325.

Wolvetang, E. J., Larm, J. A., Moutsoulas, P. and Lawen, A. (1996). Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth and Differentiation, 7 (10), 1315-1325.

De Haan, Judy B., Wolvetang, Ernst J., Cristiano, Francesca, Iannello, Rocco, Bladier, Cecile, Kelner, Michael J. and Kola, Ismail (1996). Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome. Advances in Pharmacology, 38 (C), 379-402. doi: 10.1016/S1054-3589(08)60992-8

Grubb, DR, Wolvetang, EJ and Lawen, A (1995). Didemnin-B Induces Cell-Death by Apoptosis - the Fastest Induction of Apoptosis Ever Described. Biochemical and Biophysical Research Communications, 215 (3), 1130-1136. doi: 10.1006/bbrc.1995.2580

Larm, JA, Wolvetang, EJ, Vaillant, F, Martinus, RD, Lawen, A and Linnane, AW (1995). Increase of Plasma-Membrane Oxidoreductase Activity Is Not Correlated with the Production of Extracellular-Superoxide Radicals in Human Namalwa Cells. Protoplasma, 184 (1-4), 173-180. doi: 10.1007/BF01276917

Wolvetang, EJ, Johnson, KL, Krauer, K, Ralph, SJ and Linnane, AW (1994). Mitochondrial Respiratory-Chain Inhibitors Induce Apoptosis. Febs Letters, 339 (1-2), 40-44. doi: 10.1016/0014-5793(94)80380-3

Lawen, A, Martinus, RD, McMullen, GL, Nagley, P, Vaillant, F, Wolvetang, EJ and Linnane, AW (1994). The Universality of Bioenergetic Disease - the Role of Mitochondrial Mutation and the Putative Interrelationship Between Mitochondria and Plasma-Membrane Nadh Oxidoreductase. Molecular Aspects of Medicine, 15 (SUPPL. 1), 13-27. doi: 10.1016/0098-2997(94)90009-4

Wolvetang, E. J., Tager, J. M. and Wanders, R. J. (1992). Latency of peroxisomal palmitoyl-CoA beta-oxidation in digitonin permeabilized fibroblasts: the effect of ATP on peroxisomal permeability. Progress in Clinical and Biological Research, 375, 223-229.

Wolvetang, EJ, Tager, JM and Wanders, Rja (1991). Factors Influencing the Latency of the Peroxisomal Enzyme Dihydroxyacetone-Phosphate Acyltransferase (Dhap-At) in Permeabilized Human Skin Fibroblasts. Biochimica Et Biophysica Acta, 1095 (2), 122-126. doi: 10.1016/0167-4889(91)90074-8

Wolvetang, EJ, Tager, JM and Wanders, Rja (1990). Latency of the Peroxisomal Enzyme Acyl-Coa-Dihydroxyacetonephosphate Acyltransferase in Digitonin-Permeabilized Fibroblasts - the Effect of Atp and Atpase Inhibitors. Biochemical and Biophysical Research Communications, 170 (3), 1135-1143. doi: 10.1016/0006-291X(90)90511-K

Wolvetang, EJ, Wanders, Rja, Schutgens, Rbh, Berden, JA and Tager, JM (1990). Properties of the Atpase Activity Associated with Peroxisome-Enriched Fractions From Rat-Liver - Comparison with Mitochondrial F1F0-Atpase. Biochimica Et Biophysica Acta, 1035 (1), 6-11. doi: 10.1016/0304-4165(90)90166-T

Caro, Lhp, Plomp, Pjam, Wolvetang, EJ, Kerkhof, C and Meijer, AJ (1988). 3-Methyladenine, An Inhibitor of Autophagy, Has Multiple Effects On Metabolism. European Journal of Biochemistry, 175 (2), 325-329. doi: 10.1111/j.1432-1033.1988.tb14200.x

Plomp, Pjam, Wolvetang, EJ, Groen, AK, Meijer, AJ, Gordon, PB and Seglen, PO (1987). Energy-Dependence of Autophagic Protein-Degradation in Isolated Rat Hepatocytes. European Journal of Biochemistry, 164 (1), 197-203. doi: 10.1111/j.1432-1033.1987.tb11011.x

Conference Papers

Morrison, Sean, Shaker, Mohammed, Pietrogrande, Giovanni, Wolvetang, Ernst and Noakes, Peter (2023). Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties. ISN‐ESN 2023 Meeting, Porto, Portugal, 8‐11 August 2023. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Gopalakrishnan, Aswathi, Wolvetang, Ernst, Li, Joan and Cooper-White, Justin (2022). A human iPSC-based cardiac tissue model to understand age-related heart failure. Tissue Engineering and Regenerative Medicine International Society Asia Pacific Chapter Conference (TERMIS-AP), Jeju, South Korea, 5-8 October 2022. New Rochelle, NY, United States: Mary Ann Liebert.

Cooper-White, Justin, Chowdhury, Mahfuz, Wolvetang, Ernst, Zimmerman, Samuel, Mar, Jessica, Polo, Jose, Laslett, Andrew and Nefzger, Christian (2022). Softer, faster, better! - Substrate mechanics drives superior somatic cell reprogramming outcomes. TERMIS 6th World Congress, Maastricht, Netherlands, 15-19 November 2021. New Rochelle, NY United States: Mary Ann Liebert.

Cooper-White, Justin, Chowdhury, Mahfuz, Wolvetang, Ernst and Veleva, Desi (2022). Age-dependent changes in perivascular stem cells and the impacts of altered sensing on vascular ageing. TERMIS 6th World Congress, Maastricht, Netherlands, 15-19 November 2021. New Rochelle, NY United States: Mary Ann Liebert.

Tursky, Melinda, Alateeq, Suad, Artuz, Crisbel, Loi, To Ha, Ma, David, Molloy, Tim, Tao, Helen and Wolvetang, Ernst (2021). Direct comparison of improved method for human induced pluripotent stem cell (IPSC) haematopoietic differentiation shows enhanced efficiency and sensitivity at reduced cost. ISEH 50th Annual Scientific Meeting, Online, 26 August - 30 November 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.exphem.2021.12.350

Withey, Sarah, Gerrard, Dave, Leeson, Hannah, Atkinson-Dell, Rebecca, Harrison, Sean, Baxter, Melissa, Al-Anbaki, Ali, Hanley, Karen Piper, Wolvetang, Ernst and Hanley., Neil (2020). Thyroid hormone and TGF-? inhibition drive functional maturation of human pluripotent stem cell-derived hepatocytes. EASL: The Digital International Liver Congress, Online, 27-29 August 2020. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0168-8278(20)31000-x

Slonchak, Andrii, Hugo, Leon E., Freney, Morgan, Amarilla, Alberto A., Hall-Mendelin, Sonja, Yan, Kexin, Torres, Francisco, Setoh, Yin Xiang, Peng, Nias, Chaggar, Harman K., Hurk, Andrew Van Den, Wolvetang, Ernst, Suhrbier, Andreas, Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika Virus sfRNA plays an essential role in the infection of insects and mammals. Viruses 2020—Novel Concepts in Virology, Barcelona, Spain, 5–7 February 2020. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2020050112

Shahsavari, A., Ovchinnikov, D., Wolvetang, E. and Whitworth, D. (2018). Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry, Wolvetang, Ernst and Whitworth, Deanne (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.

Woodruff, Trent M., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Leel, John D., Sepehrband', Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Coulthard, Liam G. (2017). Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, 8-12 September 2017. Kidlington, Oxford United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.178

Naidoo, Taryn, Frith, Jessica, Menzies, Donna, Pradal, Clementine, Cameron, Andrew, Wolvetang, Ernst, Grondahl, Lisbeth, Whitehead, Darryl, Gronthos, Stan, Zannettino, Andrew, Ghosh, Peter and Cooper-White, Justin (2016). Chondro-inductive injectable hydrogels for stem cell-based intervertebral disc tissue engineering. 10th World Biomaterials Congress, Montreal, Canada, 17-22 May 2016. Lausanne, Switzerland: Frontiers Research Foundation. doi: 10.3389/conf.fbioe.2016.01.02659

Schumann, Gerald, Jung-Klawitter, Sabine, Fuchs, Nina V., Upton, Kyle R., Munoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Gerdes, Patricia, Merkert, Sylvia, Pulgarin, Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltan, Izsvak, Zsuzsanna, Garcia-Perez, J. and Faulkner, Geoffrey J. (2016). Reprogramming initiates mobilization of endogenous mutagenic LINE-1, Alu and SVA retrotransposons in human induced pluripotent stem cells with consequences for host gene expression. Frontiers of Retrovirology Conference 2016, Erlangen, Germany, 12 - 14 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s12977-016-0294-5

Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, C. S., Bellingham, M., Noakes, P., Lim, Y. C., Barnett, N., Dingwall, S., Wolvetang, E., Mashimo, T., Roberts, T. and Lavin, M. (2016). Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Titmarsh, D., Glass, N., Hudson, J., Hidalgo, A., Porrello, E., Little, M., Wolvetang, E. and Cooper-White, J. (2015). Multiplexed Microbioreactor Arrays for Rapid Optimisation of Pluripotent Stem Cell Maintenance and Differentiation. 4th TERMIS World Congress, Boston Ma, Sep 08-11, 2015. NEW ROCHELLE: MARY ANN LIEBERT, INC.

Whitworth, D. J., Gauthier, M.-E., Ovchinnikov, D. A., Grimmond, S. M., Marshall Graves, J. A. and Wolvetang, E. J. (2015). Platypus Induced Pluripotent Stem Cells Reveal that Acquisition of SOX2 Responsiveness Facilitated Expansion of the Pluripotency Network During Mammalian Evolution. Annual Meeting of the International Society for Stem Cell Research, Stockholm , Sweden, 24-27 June 2015.

Blair, Nicholas, Gao, Stephen, Woodbridge, Paula, Wolvetang, Ernst, Vaughan, Christopher and Sue, Carolyn (2014). Generation of cellular models of Parkinson’s disease using induced-pluripotent stem cells derived from patients with monogenic disease. Australian and New Zealand Association of Neurologists (ANZAN) Annual Scientific Meeting, Adelaide, Australia, 18-22 May 2014. London, United Kingdom: Churchill Livingstone. doi: 10.1016/j.jocn.2014.06.088

Titmarsh, P., Hudson, J., Frith, J.E., Padmanabhan, H., Hidalgo-Gonzalez, A., Glass, N., Ovchinnikov, D., Porrello, E., Wolvetang, E. and White, C.-J. (2014). Accelerating development of stem cell-derived therapies using multiplexed microbioreactor arrays. 4th International Conference on Stem Cell Engineering, Coronado, United States, 16-19 March 2014. New York, United States: American Institute of Chemical Engineers.

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2013). FGF/ERK signalling induces X chromosome inactivation in LIF-dependent equine induced pluripotent stem cells. ASSCR 2013: 6th Annual Meeting for Australasian Society for Stem Cell Research, South Bank, QLD, Australia, 27-29 October, 2013.

Hidalgo-Gonzalez, Alejandro, Ovchinnikov, Dmitry A., Hudson, James, Cooper-White, Justin and Ernst, Wolvetang (2013). A Separable Upstream Promoter of the Slc8a1 (NCX1) Gene Efficiently Marks Cardiac Cell Populations Derived from Human Pluripotent Stem Cells. Scientific Sessions of the American Heart Association on Basic Cardiovascular Sciences, Las Vegas Nv, 22 - 25 July 2013. Baltimore, MD United States: Lippincott Williams & Wilkins.

Whitworth, D. J., Sun, J and Wolvetang, E. J. (2012). The generation of induced pluripotent stem cells from human CD34+ cells reveals a sex bias in reprogramming efficiency. Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan, 13-16 June 2012.

Menzies, D. J., Cameron, A., Maisonneuve, B. G. C., Grondahl, L., Wolvetang, E. and Cooper-White, J. (2012). Enzyme mediated, oxidative crosslinking of multifunctional, branched PEG: Characterization, particle formation and stem cell encapsulation. 3rd TERMIS World Congress 2012, Vienna, Austria, 5-8 September 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/term.1586

Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. 24th International Complement Workshop (ICW), Chania, Crete, Greece, 10-15 October 2012. Jena, Germany: Urban und Fischer Verlag. doi: 10.1016/j.imbio.2012.08.116

Titmarsh D., Doran M., Wolvetang E. and Cooper-White J. (2009). Full-factorial analysis of soluble factors maintaining human embryonic stem cells with a multiplexed microbioreactor array. 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, November 1, 2009-November 5, 2009. Chemical and Biological Microsystems Society.

Davidson, K. C., Daly, R., Wolvetang, E. J., Hearn, M. T. W. and Pera, M. F. (2006). Wnt signaling in human embryonic stem cells. Stem Cells in the Age of Fluorescence Technology: the 2005 ISAC* Samuel A. Latt Conference, Goldcoast, Queensland, Australia, 6–9 November, 2005. Hoboken, N.J.: Wiley-Liss. doi: 10.1002/cyto.a.20264

Lacey, DC, Yang, YH, Hutchinson, P, Wolvetang, E, Leech, M and Morand, EF (2001). Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes. NEW YORK: WILEY-LISS.

Wolvetang, EJ, Tager, JM and Wanders, Rja (1992). Latency of Peroxisomal Palmitoyl-Coa Beta-Oxidation in Digitonin Permeabilized Fibroblasts - the Effect of Atp On Peroxisomal Permeability. 2Nd International Symp On Clinical, Biochemical, and Molecular Aspects of Fatty Acid Oxidation, Philadelphia Pa, Nov, 1991. NEW YORK: WILEY-LISS, INC.

Preprint

Shaker, Mohammed R. , Cooper-White, Justin and Wolvetang, Ernst J. (2020). Self-organizing 3D human choroid plexus-ventricle-cortical organoids.

Research Report

Dawson, Paul A., Heussler, Helen, Wolvetang, Ernst, Lee, Soohyun and Thakar, Nilay (2016). Brain cells transformed from blood: a cell model for investigating autism. Brisbane, QLD, Australia: Autism CRC.